Pesquisa | Secretaria de Estado da Saúde

1.

Two-Year Outcomes of Valoctocogene Roxaparvovec Therapy for Hemophilia A.

Mahlangu, Johnny; Kaczmarek, Radoslaw; von Drygalski, Annette; Shapiro, Susan; Chou, Sheng-Chieh; Ozelo, Margareth C; Kenet, Gili; Peyvandi, Flora; Wang, Michael; Madan, Bella; Key, Nigel S; Laffan, Michael; Dunn, Amy L; Mason, Jane; Quon, Doris V; Symington, Emily; Leavitt, Andrew D; Oldenburg, Johannes; Chambost, Hervé; Reding, Mark T; Jayaram, Kala; Yu, Hua; Mahajan, Reena; Chavele, Konstantia-Maria; Reddy, Divya B; Henshaw, Joshua; Robinson, Tara M; Wong, Wing Yen; Pipe, Steven W.

N Engl J Med ; 388(8): 694-705, 2023 02 23.

Artigo Inglês | MEDLINE | ID: mdl-36812433

2.

Gene Therapy with Etranacogene Dezaparvovec for Hemophilia B.

Pipe, Steven W; Leebeek, Frank W G; Recht, Michael; Key, Nigel S; Castaman, Giancarlo; Miesbach, Wolfgang; Lattimore, Susan; Peerlinck, Kathelijne; Van der Valk, Paul; Coppens, Michiel; Kampmann, Peter; Meijer, Karina; O'Connell, Niamh; Pasi, K John; Hart, Daniel P; Kazmi, Rashid; Astermark, Jan; Hermans, Cedric R J R; Klamroth, Robert; Lemons, Richard; Visweshwar, Nathan; von Drygalski, Annette; Young, Guy; Crary, Shelley E; Escobar, Miguel; Gomez, Esteban; Kruse-Jarres, Rebecca; Quon, Doris V; Symington, Emily; Wang, Michael; Wheeler, Allison P; Gut, Robert; Liu, Ying P; Dolmetsch, Ricardo E; Cooper, David L; Li, Yanyan; Goldstein, Brahm; Monahan, Paul E.

N Engl J Med ; 388(8): 706-718, 2023 02 23.

Artigo Inglês | MEDLINE | ID: mdl-36812434

3.

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A.

Ozelo, Margareth C; Mahlangu, Johnny; Pasi, K John; Giermasz, Adam; Leavitt, Andrew D; Laffan, Michael; Symington, Emily; Quon, Doris V; Wang, Jiaan-Der; Peerlinck, Kathelijne; Pipe, Steven W; Madan, Bella; Key, Nigel S; Pierce, Glenn F; O'Mahony, Brian; Kaczmarek, Radoslaw; Henshaw, Joshua; Lawal, Adebayo; Jayaram, Kala; Huang, Mei; Yang, Xinqun; Wong, Wing Y; Kim, Benjamin.

N Engl J Med ; 386(11): 1013-1025, 2022 03 17.

Artigo Inglês | MEDLINE | ID: mdl-35294811

4.

Factor XII contributes to thrombotic complications and vaso-occlusion in sickle cell disease.

Sparkenbaugh, Erica M; Henderson, Michael W; Miller-Awe, Megan; Abrams, Christina; Ilich, Anton; Trebak, Fatima; Ramadas, Nirupama; Vital, Shantel; Bohinc, Dillon; Bane, Kara L; Chen, Chunsheng; Patel, Margi; Wallisch, Michael; Renné, Thomas; Gruber, Andras; Cooley, Brian; Gailani, David; Kasztan, Malgorzata; Vercellotti, Gregory M; Belcher, John D; Gavins, Felicity E; Stavrou, Evi X; Key, Nigel S; Pawlinski, Rafal.

Blood ; 141(15): 1871-1883, 2023 04 13.

Artigo Inglês | MEDLINE | ID: mdl-36706361

5.

Prophylactic tranexamic acid in patients with hematologic malignancy: a placebo-controlled, randomized clinical trial.

Gernsheimer, Terry B; Brown, Siobhan P; Triulzi, Darrell J; Key, Nigel S; El Kassar, Nahed; Herren, Heather; Poston, Jacqueline N; Boyiadzis, Michael; Reeves, Brandi N; Selukar, Subodh; Pagano, Monica B; Emerson, Scott; May, Susanne.

Blood ; 140(11): 1254-1262, 2022 09 15.

Artigo Inglês | MEDLINE | ID: mdl-35667085

6.

Red cell extracellular vesicles and coagulation activation pathways.

Noubouossie, Denis F; Key, Nigel S.

Curr Opin Hematol ; 30(6): 194-202, 2023 11 01.

Artigo Inglês | MEDLINE | ID: mdl-37548370

7.

Plasma Kallikrein as a Forgotten Clotting Factor.

Kearney, Katherine J; Spronk, Henri M H; Emsley, Jonas; Key, Nigel S; Philippou, Helen.

Semin Thromb Hemost ; 2023 Apr 18.

Artigo Inglês | MEDLINE | ID: mdl-37072020

8.

Plasmin-mediated cleavage of high-molecular-weight kininogen contributes to acetaminophen-induced acute liver failure.

Henderson, Michael W; Sparkenbaugh, Erica M; Wang, Shaobin; Ilich, Anton; Noubouossie, Denis F; Mailer, Reiner; Renné, Thomas; Flick, Matthew J; Luyendyk, James P; Chen, Zu-Lin; Strickland, Sidney; Stravitz, R Todd; McCrae, Keith R; Key, Nigel S; Pawlinski, Rafal.

Blood ; 138(3): 259-272, 2021 07 22.

Artigo Inglês | MEDLINE | ID: mdl-33827130

9.

Emicizumab dose up-titration in case of suboptimal bleeding control in people with haemophilia A.

Schmitt, Christophe; Mancuso, Maria Elisa; Chang, Tiffany; Podolak-Dawidziak, Maria; Petry, Claire; Sidonio, Robert; Yoneyama, Koichiro; Key, Nigel S; Niggli, Markus; Lehle, Michaela; Peyvandi, Flora; Oldenburg, Johannes.

Haemophilia ; 29(1): 90-99, 2023 Jan.

Artigo Inglês | MEDLINE | ID: mdl-36271487

10.

Antithrombin-III mitigates thrombin-mediated endothelial cell contraction and sickle red blood cell adhesion in microscale flow.

Wulftange, William J; Kucukal, Erdem; Man, Yuncheng; An, Ran; Monchamp, Karamoja; Sevrain, Charlotte D; Dashora, Himanshu R; Owusu-Ansah, Amma T; Bode, Allison; Ilich, Anton; Little, Jane A; Key, Nigel S; Gurkan, Umut A.

Br J Haematol ; 198(5): 893-902, 2022 09.

Artigo Inglês | MEDLINE | ID: mdl-35822297

11.

Red blood cell microvesicles activate the contact system, leading to factor IX activation via 2 independent pathways.

Noubouossie, Denis F; Henderson, Michael W; Mooberry, Micah; Ilich, Anton; Ellsworth, Patrick; Piegore, Mark; Skinner, Sarah C; Pawlinski, Rafal; Welsby, Ian; Renné, Thomas; Hoffman, Maureane; Monroe, Dougald M; Key, Nigel S.

Blood ; 135(10): 755-765, 2020 03 05.

Artigo Inglês | MEDLINE | ID: mdl-31971571

12.

Thrombin activation of PAR-1 contributes to microvascular stasis in mouse models of sickle cell disease.

Sparkenbaugh, Erica M; Chen, Chunsheng; Brzoska, Tomasz; Nguyen, Julia; Wang, Shaobin; Vercellotti, Gregory M; Key, Nigel S; Sundd, Prithu; Belcher, John D; Pawlinski, Rafal.

Blood ; 135(20): 1783-1787, 2020 05 14.

Artigo Inglês | MEDLINE | ID: mdl-31977004

13.

Neutrophils: back in the thrombosis spotlight.

Noubouossie, Denis F; Reeves, Brandi N; Strahl, Brian D; Key, Nigel S.

Blood ; 133(20): 2186-2197, 2019 05 16.

Artigo Inglês | MEDLINE | ID: mdl-30898858

14.

Red blood cells modulate structure and dynamics of venous clot formation in sickle cell disease.

Faes, Camille; Ilich, Anton; Sotiaux, Amandine; Sparkenbaugh, Erica M; Henderson, Michael W; Buczek, Laura; Beckman, Joan D; Ellsworth, Patrick; Noubouossie, Denis F; Bhoopat, Lantarima; Piegore, Mark; Renoux, Céline; Bergmeier, Wolfgang; Park, Yara; Ataga, Kenneth I; Cooley, Brian; Wolberg, Alisa S; Key, Nigel S; Pawlinski, Rafal.

Blood ; 133(23): 2529-2541, 2019 06 06.

Artigo Inglês | MEDLINE | ID: mdl-30952675

15.

A pilot study of the effect of rivaroxaban in sickle cell anemia.

Ataga, Kenneth I; Elsherif, Laila; Wichlan, David; Wogu, Adane F; Matsui, Neil; Pawlinski, Rafal; Cai, Jianwen; Key, Nigel S.

Transfusion ; 61(6): 1694-1698, 2021 06.

Artigo Inglês | MEDLINE | ID: mdl-33660875

16.

Pharmacokinetics of perioperative FVIII in adult patients with haemophilia A: An external validation and development of an alternative population pharmacokinetic model.

Zhu, Jing; Wu, Yi Shuan; Beechinor, Ryan J; Kemper, Ryan; Bukkems, Laura H; Mathôt, Ron A A; Cnossen, Marjon H; Gonzalez, Daniel; Chen, Sheh-Li; Key, Nigel S; Crona, Daniel J.

Haemophilia ; 27(6): 974-983, 2021 Nov.

Artigo Inglês | MEDLINE | ID: mdl-34405493

17.

Outcomes for studies assessing the efficacy of hemostatic therapies in persons with congenital bleeding disorders.

Aquino, Camila C; Borg Debono, Victoria; Germini, Federico; Pete, Drashti; Kempton, Christine L; Young, Guy; Sidonio, Robert; Croteau, Stacy E; Dunn, Amy L; Key, Nigel S; Iorio, Alfonso.

Haemophilia ; 27(2): 211-220, 2021 Mar.

Artigo Inglês | MEDLINE | ID: mdl-33550614

18.

Coagulation Abnormalities and Thrombosis in Patients Infected With SARS-CoV-2 and Other Pandemic Viruses.

Mackman, Nigel; Antoniak, Silvio; Wolberg, Alisa S; Kasthuri, Raj; Key, Nigel S.

Arterioscler Thromb Vasc Biol ; 40(9): 2033-2044, 2020 09.

Artigo Inglês | MEDLINE | ID: mdl-32657623

19.

Pregnancy in sickle cell trait: what we do and don't know.

Wilson, Samuel; Ellsworth, Patrick; Key, Nigel S.

Br J Haematol ; 190(3): 328-335, 2020 08.

Artigo Inglês | MEDLINE | ID: mdl-32064587

20.

D-Dimer Enhances Risk-Targeted Thromboprophylaxis in Ambulatory Patients with Cancer.

Kumar, Vaibhav; Shaw, Joseph R; Key, Nigel S; Ilich, Anton; Mallick, Ranjeeta; Wells, Philip S; Carrier, Marc.

Oncologist ; 25(12): 1075-1083, 2020 12.

Artigo Inglês | MEDLINE | ID: mdl-32969580

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